Secondary lung abscess is the abscess formed by co-infection on top of the primary lung diseases. The formation of the lung abscess will make the treatment of the primary lung diseases difficult, especially if it is secondary to lung cancer. The therapy of lung cancer is a comprehensive treatment based on surgery. But the inflammatory environment, tissue adhesion, and risk of pus cavity rupture brought by lung abscess can increase the difficulty and risk of surgery. Here, we report a case of acute lung abscess secondary to lung cancer, which was discharged after surgical treatment.