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Benign ulcerations of the oral mucosa may have a similar appearance to malignant lesions [1, 2]. There are several conditions, both local and systemic, that can manifest as oral ulcers, and that can correspond, on many occasions, to both infectious and autoimmune causes. Probable etiology can often be determined by a complete medical history and a careful physical examination. However, on several occasions, an exhaustive diagnostic study will be necessary, counting on a range of diagnostic suspicions